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The most common user-reported experience: Temporary skin dryness in week 1 (resolves by week 2) Occasional injection site redness (standard for any subQ peptide) Some users report increased hair growth, including in unintended areas at higher doses At doses above 34 mg/day, some protocols note headaches, but this is well above standard dosing
Combined with above-mentioned data, GLP-1RAs show a positive impact on the suppression of NLRP3 inflammasome (Figure 2)
Helps combat hair loss as it supports hair shine, strength, and volume
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
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